One of the most widely-used staging systems is the Butchart Staging System. This system includes four stages.
Stage I - The mesothelioma occurs in the left or right side membrane that lines the lungs. This may include the presence of mesothelioma in the membrane sac that covers the heart, the lung, or the diaphragm on the same side.
Stage II - The mesothelioma has spread to other areas, e.g. the chest wall, esophagus, heart or pleura.
Stage III - The mesothelioma has broken into the diaphragm to the lining of the abdomen.
Stage IV - The cancerous cells have entered the bloodstream, allowing the spread of the disease to other organs.
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